Efforts to prevent the abuse of khamr in Simeulue Regency refer to the Aceh Governor Regulation (Pergub) Number 10 of 2005 which regulates the supervision and prosecution of the circulation and consumption of khamr. In the regulation, it is stated that one of the elements that have an important role in supervision is Wilayatul Hisbah (WH). This research is a type of empirical legal research or known as nondoktrinal research which is qualitative in nature that emphasizes the process and operation of law in society. The results of this study indicate that so far the role of Wilayatul Hisbah Simeulue Regency has not been running optimally, due to various internal and external obstacles faced by Wilayatul Hisbah, such as limited personnel, lack of operational budget, and lack of cross-sector coordination with related agencies. Therefore, to maximize the role of Wilayatul Hisbah in preventing khamr cases, several strategic steps are needed, including: increasing the capacity of WH human resources, providing adequate facilities and infrastructure, and strengthening coordination between WH, police, and community leaders. In addition, an educative and preventive approach is needed, not only repressive, to build public awareness of the dangers and prohibitions of khamr consumption according to Islamic law and positive law in Aceh.