This research aims to reveal the knowledge of how 5-6 year old preschoolers wash their hands with soap by employing Team Games Tournament Smart Cards method in TKIT of Baitul Izzah Bengkulu. This research uses pre-experimental method with 33 preschoolers as the sample. The instrument used is a questionnaire and the data analysis utilizes T-test as the alternative test with 5% margin of error. The result of T-test from the handwashing knowledge with soap, before and after being given the Team Games Tournament Smart Card method is p value < 0,043. The knowledge after being given the Team Games Tournament Smart Card method is 10,02. Therefore, it is concluded that the Team Games Tournament Smart Card method is proven effective in delivering knowledge about handwashing with soap among 5-6yearold preschoolers in TKIT of BaitulIzzah Bengkulu. It is expected that the Team Games Tournament Smart Card method can be an alternative in teaching the appropriate knowledge for preschoolers based on their age characteristics.